DUBAI—Iran has been urgently signaling that it seeks an end to hostilities and resumption of talks over its nuclear programs, sending messages to Israel and the U.S. via Arab intermediaries, Middle Eastern and European officials said.

At least 224 people have been killed in Iran by Israeli strikes, Netanyahu's office said on Monday. The Israel Defense Forces issued a warning to residents in District 3 of Tehran to "immediately leave" ahead of planned strikes there.

TEL AVIV, Israel (AP) — Iran fired a new wave of missile attacks on Israel early Monday, killing at least five people, while Israel claimed in the fourth day of the conflict that it had now achieved “aerial superiority” over Tehran and could fly over the Iranian capital without facing major threats.

Israel struck buildings in Tehran belonging to the Islamic Republic of Iran Broadcasting, or IRIB, Iran's state-owned media company, with the blasts seemingly heard live on television hours after the Israeli military said residents and workers in that part of the capital should leave.

The Israeli military claims its campaign has eliminated high-value targets, including nine senior scientists, and severely damaged Iran’s nuclear infrastructure. Iranian authorities confirmed damage to four critical buildings at the Isfahan uranium conversion facility,

As Israel and Iran trade fire, Tehran's state-backed crypto mining and 300K BTC holdings draw fresh scrutiny for their role in navigating sanctions and supporting the digital economy.

Tehran has asked Qatar, Saudi Arabia and Oman to press U.S. President Donald Trump to use his influence on Israel to agree to an immediate ceasefire with Iran in return for Tehran's flexibility in nuclear negotiations,

The Iranian regime faces pressure as Israel strikes military targets, with Iranian Americans advocating for the overthrow of what one Iranian American describes as a "paper tiger regime."

Since Israel began its concerted attack on Iran on Friday, calls for regime change in Iran have grown louder – from hawks in the US Congress to Israeli officials and some Iranian activists abroad.

Hundreds of civilians, mostly in Iran, have been killed by dueling airstrikes despite international pleas for de-escalation.

Iran conflict could open opportunities for Russia to possibly become a power broker to help end the confrontation.