Interstate 80 was closed in Green River after the crash and will likely remain so until at least Wednesday, officials said. The roadway runs from San Francisco nearly to New York City.

At least two people were killed in a "multi-vehicle crash" in an interstate tunnel, Wyoming authorities confirmed Friday.

The crash occurred at 11:37 a.m. under a snow-dusted hill in Green River, Wyo., according to the State Transportation Department. By 5 p.m., the tunnel, which leads traffic west on Interstate 80, had been evacuated and the scene had “been contained,” the department said in a statement.

The eastbound Green River tunnel on Interstate 80 has reopened almost a week after a fiery crash that left three people dead.

A fiery pileup at a tunnel on Interstate 80 in southwestern Wyoming killed at least two people, seriously injured at least five others and shut down the highway.

Wyoming Highway Patrol troopers said that the crash involved semi-trucks and passenger vehicles, and added that the strong heat was causing tires to explode.

Wyoming authorities have entered a highway tunnel to begin picking through the wreckage of a fiery multivehicle crash a day earlier

Authorities have confirmed a third person died in the massive wreck and fire that ignited Friday in the Green River Tunnel on Interstate 80.

Another person has been confirmed dead as the investigation continues into a major, multi-vehicle crash in the westbound tunnel of I-80 in Green River, Wyoming, according to the Wyoming Dept. of Transportation.