Walgreens is planning to close around 1,200 locations, as the drugstore chain and its rivals struggle to define their role for U.S. shoppers who no longer look to them first for convenience.

Walgreens is set to close around 1,200 stores as it, along with other drugstore chains, faces challenges in staying relevant to shoppers.

The pharmacy giant estimates that a quarter of its 8,700 locations are unprofitable as consumers shift their spending habits.