Tens of millions of people living in the Midwest and central U.S. could be impacted by tornadoes on Wednesday while critical wildfire conditions continue to impact the Southwest, after recent wildfires and a tornado outbreak killed at least 42 people over the weekend.

Another storm system is affecting millions of people in the middle of the U.S. Parts of the Midwest and Great Plains faced blizzard conditions Wednesday and a broad swath of neighboring states are at risk of high winds and wildfires.

Strong tornadoes are possible near Chicago, while blizzard conditions have been blasting Nebraska and Kansas. Farther south, Oklahoma and Texas are facing critical wildfire danger.