Notably, this coupling crumbles with age in mice. Restoring it not only bolstered neuronal energy reserves, but also strengthened synaptic signaling and counteracted memory loss in old animals.

The easiest way to track down "when" in a chronic disorder like AD is with the causal quartet, those carrying disease-causing mutations in APP, PSEN1, PSEN2 and SORL1, and, as you expand, including ...

While all three genotypes of mice performed similarly to wild-type animals on multiple behavioral and spatial memory tests, ...

This letter was prompted by your recent perspective paper and the responses it provoked in an Alzforum discussion. Generally, my comments are offered with the intellectual humility required when ...

SIRT6 in AD? DNA damage and oxidative stress reduce the level of SIRT6 deacetylase in aging, leading to more acetylated APP. This prevents APP ubiquitination and destruction in the proteasome and ...

Erik Johnson at Emory University, Atlanta, agreed MR-SPI is an advance. “The authors’ algorithm addresses a number of challenges with Mendelian randomization using proteomics data. An advantage of ...

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