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Opinion editorials: the science and art of combining evidence with opinion
3 Manitoba Centre for Health Policy, Department of Community Health Sciences, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada Correspondence to: Gregory P Marchildon ...
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63 Overdiagnosis in the frail elderly population – empirical and ethical issues and a conceptual model to guide change
Overdiagnosis has been described as ‘unwarranted diagnosis’ (Moynihan et al, 2018). It is the formulation and conveyance of a label –generally of a disease or condition - that can lead to patient harm ...
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Users' Guides to the Medical Literature
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Expanded disease definitions in Alzheimer’s disease and the new era of disease-modifying drugs
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Different knowledge, different styles of reasoning: a challenge for guideline development
Correspondence to Dr Sietse Wieringa, Department of Continuing Education, University of Oxford, Oxford OX1 2JA, UK; sietse.wieringa{at}kellogg.ox.ac.uk Evidence-based guidelines whether national, ...
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External validity, generalisability, applicability and directness: a brief primer
Correspondence to Dr Mohammad H Murad, Evidence-Based Practice Center, Mayo Clinic, Rochester, MN 55905, USA; murad.mohammad{at}mayo.edu Although random sampling can lead to more generalisable results ...
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Antenatal magnesium sulfate treatment for women at risk of preterm birth is safe and might decrease the risk of cerebral palsy
Correspondence to Dr. Lene Drasbek Huusom, Department of Gynecology/Obstetrics, Region Hovedstaden, Hvidovre 72735, Denmark; Lene.Drasbek.Huusom{at}regionh.dk If you wish to reuse any or all of this ...
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Expanding the measurement of overdiagnosis in the context of disease precursors and risk factors
Correspondence to Dr Guylene Theriault, Department of Family Medicine, McGill University, Montreal, QC H3S 1Z1, Canada; guylene.theriault{at}mcgill.ca Because individual patients weigh benefits and ...
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Among statin-treated patients, LDL, non-HDL and apoB cholesterol biomarkers were associated with increased risks of cardiovascular events
Correspondence to: Allan David Sniderman, Department of Medicine/Cardiology, McGill University, Royal Victoria Hospital, 687 Pine Avenue West, Room H7.22, Montreal, Quebec, Canada H3A 1A1; ...
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Atrial fibrillation is associated with an increased risk of cognitive impairment and dementia with or without a history of clinical stroke
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy Correspondence to: Dr Paola Forti Department of Medical and Surgical Sciences, University of Bologna, Via Massarenti ...
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Blinding in randomised clinical trials of psychological interventions: a retrospective study of published trial reports
Objectives To study the extent of blinding in randomised clinical trials of psychological interventions and the interpretative considerations if randomised clinical trials are not blinded. Design ...