Warren held Boston scoreless through four innings, then surrendered a home run to 22-year-old Marcelo Mayer to lead off the fifth. It was the first career homer for Mayer, one of baseball’s premier prospects, in his 10th MLB game.

With lefty Brent Headrick replacing Warren, Cora turned to Romy Gonzalez and Rob Refsnyder, two of the best pinch-hitters on the roster, to bat in place of Mayer and David Hamilton. Gonzalez quickly plated two runs with a single, but Trevor Story and Refsnyder followed with a pair of foul-tip strikeouts to leave two men in scoring position.