Background Colorectal cancer (CRC) is a common and preventable disease for which screening rates by colonoscopy remain unacceptably low. Our primary objective was to develop and validate a clinical ...

Background Mounting epidemiological evidence supports a role for phosphatase and tensin homologue (PTEN)-T cell leukaemia 1 (Tcl1) signalling deregulation in hepatocarcinogenesis. Objective To ...

Objective Chronic pancreatitis is a progressive inflammatory disorder of the pancreas characterised by permanent destruction of acinar cells. Mutations in the chymotrypsinogen C (CTRC) gene have been ...

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2 Center for Functional Gastrointestinal and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA 3 Translational Research Center for Gastrointestinal ...

Correspondence to Dr Citadel J Cabasag, Cancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France; cabasagc{at}fellows.iarc.fr We read with interest the commentary by ...

Correspondence to Dr Feng Sun, Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing 100191, China; sunfeng{at}bjmu.edu.cn SS and QY contributed equally.

Objective Cancer-associated fibroblasts (CAFs) influence the tumour microenvironment and tumour growth. However, the role of CAFs in colorectal cancer (CRC) development is incompletely understood.

1 Department of Gastroenterology, Barts and The London NHS Trust, London, UK 2 Upper Gastrointestinal Physiology Unit, Barts and the London School of Medicine and Dentistry, London, UK 3 Department of ...

1 Dalhousie Inflammation Group and Department of Pediatrics, and Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada 2 Dalhousie Inflammation Group and ...

Histopathology Unit, Imperial Cancer Research Fund, Royal College of Surgeons, London. Diet is of fundamental importance in the healthy functioning of alimentary epithelium, or during the disease ...

1 Mech-Sense, Department of Gastroenterology, Aalborg University Hospital, Aalborg, Denmark 2 Center for Sensory-Motor Interactions, Department of Health Science and Technology, Aalborg University, ...