Notably, this coupling crumbles with age in mice. Restoring it not only bolstered neuronal energy reserves, but also strengthened synaptic signaling and counteracted memory loss in old animals.

The easiest way to track down "when" in a chronic disorder like AD is with the causal quartet, those carrying disease-causing mutations in APP, PSEN1, PSEN2 and SORL1, and, as you expand, including ...

• PhD, Yonsei University College of Medicine, Seoul, Korea 2008 • MS, Yonsei University College of Medicine, Seoul, Korea 2000 • MD, Yonsei University College of Medicine, Seoul, Korea 1997 ...

Dennis J. Selkoe, M.D. The Vincent and Stella Coates Professor of Neurologic Diseases, Harvard Medical School. Co-Director, Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s ...

While all three genotypes of mice performed similarly to wild-type animals on multiple behavioral and spatial memory tests, ...

Many genes and proteins have been linked to Alzheimer’s, but which ones directly contribute to disease? This question has been hard to answer. In the December 11 Cell Genomics, scientists led by ...

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SIRT6 in AD? DNA damage and oxidative stress reduce the level of SIRT6 deacetylase in aging, leading to more acetylated APP. This prevents APP ubiquitination and destruction in the proteasome and ...